Energy & fatigue
NAD+ and daily energy: what the science supports, and what it doesn't
If you are sleeping eight hours and still dragging at 2pm, the honest answer starts with what NAD+ does in a mitochondrion — and with what no supplement can promise you.
Try your first box — $25No caffeine · no crash · 30-day money-back guarantee
NAD+ is the coenzyme that carries electrons through the reactions that turn food into ATP — the cell's usable energy currency. That is textbook biochemistry, not marketing. What is not established is that taking an NAD+ precursor makes a healthy person feel more energetic; trials have measured blood NAD+ levels far more often than they have measured how people feel. We support cellular energy metabolism. We are not going to promise you a mood.*
Where NAD+ sits in energy production
Every calorie you eat has to be converted into ATP before a cell can spend it. NAD+ is the shuttle in that conversion: it accepts electrons during glycolysis and the citric acid cycle, becomes NADH, and hands those electrons to the electron transport chain in the mitochondria. Without adequate NAD+, that chain has less to work with. This is why NAD+ is described as central to cellular energy metabolism.*
What the human trials actually measured
This is where we part company with most NAD+ marketing. Trammell and colleagues demonstrated that oral NR is bioavailable and raises blood NAD+ in humans.1 Martens and colleagues confirmed elevated NAD+ over six weeks of dosing and reported good tolerability.2 Conze and colleagues ran a randomized, double-blind, placebo-controlled trial and reported safety over longer-term use.3
Notice what those endpoints are: NAD+ levels and safety. They are not "participants reported feeling less tired." If a brand shows you a percentage of customers who "felt more energetic," ask where that number came from. Ours would be made up, so we do not have one.
Things that beat a supplement for afternoon energy
We would rather you know this than buy something that cannot fix your actual problem:
- Sleep debt is not repaid by any capsule or packet.
- An afternoon caffeine crash is usually a caffeine timing problem, not a nutrient problem.
- Iron, B12, thyroid and sleep apnea are common, testable causes of persistent fatigue. If you are exhausted despite sleeping well, get bloodwork before you get supplements.
NAD+ support is a daily foundation, not a rescue. If your fatigue has a medical cause, treat the cause.*
One packet. Ten seconds. No caffeine.
600mg nicotinamide riboside plus quercetin phytosome, trans-resveratrol and PQQ — in a sweet berry shot you drink straight from the packet.
Try your first box — $25 Free US shipping · 30-day money-back guaranteeWhy no caffeine
Because a stimulant would make the product feel like it is working while doing nothing for the underlying pathway. If you want a jolt, coffee is cheaper and faster. simplyNAD+ is for the other job: giving your cells the NAD+ precursor supply, every day, without a crash on the other side.*
Frequently asked
Will this give me an energy boost like coffee?
No, and it is not designed to. There is no caffeine or stimulant in it. It supports cellular energy metabolism, which is a slower, foundational thing than a stimulant hit.*
How long until I feel something?
We will not give you a number, because the human trials measured NAD+ levels rather than how people felt. Give it 30 days — that is what the money-back guarantee is for.
When should I take it?
Most people take it in the morning because it is the easiest habit to keep. There is no evidence requiring a specific time.
Can I take it with coffee?
Yes. There is no known interaction, and no caffeine in the packet to stack on top.
I'm tired all the time. Is this the answer?
Possibly not. Persistent fatigue despite good sleep deserves actual bloodwork — iron, B12, thyroid and sleep apnea are common and treatable. Please rule those out first.
References
- Trammell SAJ, Schmidt MS, Weidemann BJ, et al. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nature Communications. 2016;7:12948.
- Martens CR, Denman BA, Mazzo MR, et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nature Communications. 2018;9:1286.
- Conze D, Brenner C, Kruger CL. Safety and metabolism of long-term administration of NIAGEN (nicotinamide riboside chloride) in a randomized, double-blind, placebo-controlled clinical trial of healthy overweight adults. Scientific Reports. 2019;9:9772.
- Massudi H, Grant R, Braidy N, et al. Age-associated changes in oxidative stress and NAD+ metabolism in human tissue. PLoS ONE. 2012;7(7):e42357.
Keep reading
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. simplyNAD+ is a dietary supplement, not a medicine. If you are pregnant, nursing, taking medication or managing a health condition, speak with your doctor before use.