Healthy aging
NAD+ and healthy aging: the cellular case, without the hype
Creams work on the surface. NAD+ works in the part of the cell that makes the energy everything else runs on. Here is what that means — and the claims we refuse to make.
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NAD+ is consumed by sirtuins and PARP enzymes — the families involved in cellular housekeeping and DNA repair — and human tissue studies report NAD+ declines with age.1 Supporting NAD+ is therefore a reasonable foundation for healthy aging. What no honest brand can tell you is that a supplement will change how your face looks by a specific date. We support healthy aging at the cellular level. We do not sell wrinkle results.*
Why "cellular" is not a buzzword here
Skin is a tissue with a high turnover rate, which means it is energy-hungry. The enzymes involved in repair — PARPs — consume NAD+ directly when they work. Sirtuins, involved in cellular housekeeping, do the same. So NAD+ availability is genuinely upstream of a lot of maintenance biology. That is the real reason NAD+ shows up in longevity conversations.*
What follows from that is modest and honest: keeping the precursor supply topped up is a sensible daily foundation. It is not a facelift, and any brand implying otherwise is selling you a claim it cannot support.
The claims we will not make
You have seen these on other NAD+ and beauty pages. We do not make any of them, and here is why:
| Common claim | Why we don't say it |
|---|---|
| "Reverses aging" | No supplement has shown this in humans. Aging is not a disease and this crosses into drug-claim territory. |
| "Visible results in 30 days" | We have no trial measuring appearance. Saying it would be inventing data. |
| "98% absorption" | A number we have never measured. Absorption percentages on supplement pages are almost always fabricated. |
| "Clinically proven to reduce wrinkles" | Our formula has not been through a wrinkle trial. Ingredient studies are not product studies. |
| "Doctor-formulated" | Only true if a doctor formulated it. Ours was not. |
We would rather lose the sale than print a number we cannot stand behind. That is also why the reviews on this site are real reviews of this formula, not invented testimonials.
Four actives, one berry packet
600mg nicotinamide riboside, 250mg quercetin phytosome, 150mg trans-resveratrol and 40mg PQQ. Dairy-free, gluten-free, ships from the USA.
Try your first box — $25 Free US shipping · 30-day money-back guaranteeWhat is realistic to expect
- A habit you keep. Ten seconds beats eight capsules, and the supplement that works is the one you actually take.
- A dose inside the studied range. 600mg NR sits within the range used in published human trials.2,3
- No stimulant, no crash. There is no caffeine in it.
- A real exit. 30-day money-back guarantee, and you can .
Frequently asked
Will this help my skin?
We support healthy aging at the cellular level, which is upstream of skin maintenance. We have not run a skin trial on this formula and will not claim visible results.*
Is NAD+ anti-aging?
NAD+ declines with age in human tissue and is consumed by repair enzymes, which is why it features in longevity research. That is a mechanism, not a promise that a supplement reverses aging.
How is this different from a collagen powder?
Different target entirely. Collagen supplies a structural protein; NAD+ precursors support the energy and repair pathways inside cells. They are not substitutes for each other.
Are your reviews real?
Yes. The ratings shown are real reviews of this formula, including three- and four-star ones. We do not write testimonials or use stock people as customers.
Can I take it long term?
Long-term NR administration has been studied in a randomized, double-blind, placebo-controlled trial and reported as well tolerated.4 As always, if you take medication or are pregnant or nursing, ask your doctor first.
References
- Massudi H, Grant R, Braidy N, et al. Age-associated changes in oxidative stress and NAD+ metabolism in human tissue. PLoS ONE. 2012;7(7):e42357.
- Trammell SAJ, Schmidt MS, Weidemann BJ, et al. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nature Communications. 2016;7:12948.
- Martens CR, Denman BA, Mazzo MR, et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nature Communications. 2018;9:1286.
- Conze D, Brenner C, Kruger CL. Safety and metabolism of long-term administration of NIAGEN (nicotinamide riboside chloride) in a randomized, double-blind, placebo-controlled clinical trial of healthy overweight adults. Scientific Reports. 2019;9:9772.
Keep reading
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. simplyNAD+ is a dietary supplement, not a medicine. If you are pregnant, nursing, taking medication or managing a health condition, speak with your doctor before use.